Toll-like receptors (TLRs) are immune receptors localized to the cell surface or intracellular compartments like the endosome. TLRs’ ability to recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) make them key players in innate immunity. When activated by PAMPs or DAMPs, TLRs recruit Toll/IL-1 receptor (TIR) domain-containing adaptor proteins, like MyD88, to trigger other signal transduction pathways and amplify downstream signals that eliminate the microbial infection. In cases of excessive immune responses, insufficient negative regulation of TLR signaling has been linked with autoimmunity and inflammatory diseases. Click below to view & download the toll-like receptors pathway.
Boster takes great measures to ensure product quality and to provide our customers with comprehensive data upfront. Our antibodies are validated using WB, IHC, and flow cytometry against a panel of over 250 tissues and un-transfected cell lines to ensure high affinity and crystal-clear IHC stains. In addition, we also validate our antibodies in a quantitative fashion by testing them on known quantities of recombinant proteins so that you know what to expect (e.g. if there is 1ng, 2.5ng or 5ng of the target protein in the sample). Every product is covered by the Boster Quality Guarantee, click below to learn more.
