Mesothelin, also known as MSLN, is a cell surface glycoprotein encoded by the MSLN gene. The MSLN gene encodes a 71 KD precursor protein, which is hydrolyzed by furin protease into two parts: megakaryocyte-potentiating factor (MPF) and MSLN.
Mesothelin may play a role in adhesion. With the deepening of research on tumor, mesothelin has been found to play an important role in the development of various tumors. Given that mesothelin is highly expressed in a variety of human malignant cells and is rarely expressed in normal tissues, mesothelin is expected to be a target for specific treatment of tumors.
The MSLN protein provided by CUSABIO has high purity and its activity was determined by functional ELISA.
Product Card
Product Name: Recombinant Human Mesothelin(MSLN),partial (Active)
Code: CSB-MP015044HUc9
Species: Homo sapiens
Purity: Greater than 92% as determined by SDS-PAGE.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Protein purity is greater than 92% as determined by SDS-PAGE.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/mL can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/mL.
Pleural mesothelioma, Mesothelioma, Breast cancer, Lung cancer, Metastatic cancer
MCY-M11
MaxCyte
Phase Ⅰ
Pleural mesothelioma, Ovarian cancer
KD-021 (Nanjing KAEDI Biotech)
Nanjing KAEDI Biotech
Phase Ⅰ
Solid tumours
RG-7600
Genentech
Phase Ⅰ
Ovarian cancer, Pancreatic cancer
RNA-Meso-CIR-T
University of Pennsylvania, Novartis
Phase Ⅰ
Mesothelioma
Amatuximab
National Cancer Institute, Morphotek
Phase Ⅱ
Mesothelioma, Solid tumours, Pancreatic cancer
Anetumab ravtansine
Bayer, MorphoSys
Phase Ⅱ
Non small cell lung cancer (NSCLC), Mesothelioma, Solid tumours
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)
Shanghai Cell Therapy Research Institute
Phase Ⅱ
Solid tumours
BMS-986148
Bristol-Myers Squibb
Phase Ⅱ
Solid tumours
LMB-100
Roche, National Cancer Institute, Selecta Biosciences
Phase Ⅱ
Mesothelioma, Pancreatic cancer
If you are interested in MSLN, please click on this article: Mesothelin: A Rising Star of Cancer Immunotherapy. Here, you can learn information about MSLN: Structure, __expression__, function, and clinical drug.
