Model Showcase: STZ-Induced Diabetic Neuropathy

Streptozotocin (STZ) is commonly used to induce type I diabetes and diabetes-related complications including diabetic peripheral neuropathy. STZ induces diabetes through its potent toxicity to pancreatic beta cells, however, the specific mechanisms by which neuropathy is induced is not fully understood. Research has implicated hyperglycemia related inflammatory processes and blood supply interference via ischemia of the micro vessels may be damaging nerve endings.  

Other studies indicate STZ directly causes neuronal damage as reactive oxygen species (ROS) mediate elevation of TRPV1 in neurons and the dorsal root ganglia (DRG) is exposed to STZ in vitro. Therefore, this model does involve direct changes in the nerves that are not related to the inflammatory process.

Model Specifications at MD Biosciences: