The lung bronchial, tracheal, and small airway tree is lined with a continuous cellular layer of epithelial cells that act as frontline defense against respiratory pathogens. The epithelial interface between environment and organism functions in particulate clearance, fluid balance, mucus and surfactant production, and injury repair.
As the world faces the COVID-19 pandemic crisis, research models are more important than ever as scientists race to develop effective treatments and vaccines for the SARS-CoV-2 coronavirus.
To support COVID-19 and respiratory system research, Cell Applications, Inc. offers Primary Airway Cell models of the respiratory system. The convenient Total Kits include cells and optimized media specific to each cell type.
AEC2 / i-HAEpC2 Top: Phase contrast, 100x. Bottom left and right: Immunostaining for SPTPC (green) and NKX2.1 (red), 200x.
Alveolar type 2 cells (AEC2) function in ion transport and epithelium repair, as well as in the defense and immune response against microorganisms. AEC2 secrete surfactant proteins, release a host of factors that include cytokines and chemokines, and present antigen to specific T cells.
Cell Applications' AEC2 / i-HAEpC2 are Type 2 Alveolar Epithelial Cells that were derived from induced pluripotent stem cells with Cell Applications' unique technology. iPSC undergo multistage differentiation to AEC2, and are characterized by staining for NK2 homeobox 1 (NKX2-1), a marker for lung differentiation lineage, and Surfactant protein C (SFTPC), a marker for Alveolar Type 2 cells.
i-Alveolar Epithelial Cell Total Kits includes cryopreserved AEC2, optimized growth medium, coating medium, and dissociation solution.
