MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 25,000 bioactive molecules in stock
• High purity & competitive prices
• Target 375 key proteins in 20+ signaling pathways
• Data sheet with detailed biological information
• Quality reports (LC/MS, NMR and HPLC) for each product
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• Release more than 500 of the newest biochemicals per month
AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
IM156 (HL156A; HL271 acetate), a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.
K00546 is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively.
Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death.
TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3).
1. Cell. 2020 Aug 6;182(3):545-562.e23. 2. Cancer Cell. 2020 Jul 30;S1535-6108(20)30369-X. doi:10.1016/j.ccell.2020.07.008. 3. Cell Metab. 2020 Aug 4;32(2):287-300.e7. 4. Cell Stem Cell. 2020 Jul 14;S1934-5909(20)30288-5. doi:10.1016/j.stem.2020.06.021.
