Creative-biolabs) It's Not Too Late to Reduce Immunogenicity of Monoclonal Antibodies      
작성자
abbabio
작성일자
2020-09-25
조회수
242
Some rodent antibodies with antigen specificity are of therapeutic interest, but they are highly immunogenic in humans, which limits their clinical applications, especially when repeated administrations are required. They could be rapidly removed from the circulation and can cause systemic inflammatory effects as well. Therefore, humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources and for improving their activation of the human immune system.
Creative Biolabs has developed three antibody humanization strategies that can preserve the antibody specificity and affinity while eliminating the immunogenicity in humans: CDR grafting & SDR grafting, chain shuffling, and humanized IgG library screening. We have succeeded in 15 mouse/rat humanization projects during the past decade and at least one humanized antibody entered the clinical trials.
Shirley, NY 11967, USA Tel: 1-631-381-2994 Fax: 1-631-207-8356 Website: www.biolabsantibody.com
