As a supplier of biochemical products, BOC Sciences now offers antibody-drug conjugates (ADCs) payloads for your ADC discovery and design.
Production Capacity
• 5L-1,000L reactors
• Support your IND, NDA and/or ANDA applications
• High-potency workshop for Non-GMP and GMP productions
• Advanced equipment
Quality & Documents
• Purity of not less than 95%
• Provide Certificate of Analysis, SDS, and related spectra
• GMP manufacturing
• A DMF application plan
Table below presents some of our ADC payloads
CAS
Product Name
Application
108212-75-5
Calicheamicin γ1
Binding to the minor groove of DNA and delivering cytotoxin to the target, causing strand scission.
108212-76-6
N-Acetyl-Calicheamicin
A derivative of Calicheamicin that could be a potential cytotoxic DNA-binding agent.
169869-90-3
Exatecan Mesylate
A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity.
20830-81-3
Daunorubicin
Inhibiting both DNA and RNA synthesis.
23214-92-8
Doxorubicin
An antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
56420-45-2
Epirubicin
A semisynthetic L-arabino derivative of doxorubicin. An antineoplastic agent by inhibiting Topoisomerase.
1445-07-4
Pseudouridine
RNA-derived modified ribonucleosides for vaccine and cancer research.
77327-05-0
Didemnin B
A cyclic depsipeptide isolated from the extract of Trididemnum solidum. It exhibits antiviral and antineoplastic effects.
138626-63-8
Deoxymuludocandin
An echinocandin antifungal isolated from Aspergillus sydowii.
23110-15-8
Fumagillin
An antimicrobial agent used in the treatment of microsporidiosis.
62996-74-1
Staurosporine
Broad spectrum protein kinase inhibitor.
87081-35-4
Leptomycin B
A potent anti-fungal antibiotic.
99533-80-9
K252a
A protein kinase inhibitor and exhibit antitumor activity to some extent.
146478-72-0
Fr901464
Potent antitumor activities against tumor cell lines via binding to the spliceosome and modulating pre-mRNA splicing.
437742-34-2
Marizomib
Potential antineoplastic activity.
128517-07-7
Romidepsin
An anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs).
127785-64-2
Aureobasidin A
A cyclic depsipeptide antibiotic isolated from the filamentous fungus Aureobasidium pullulans R106.
1426953-21-0
Thailanstatin A
Can be used as a payload for ADCs.
62182-86-9
Dihydrocarminomycin
An anthracycline antibiotic.
96702-03-3
Ectoine
A protective substance by acting as an osmolyte and thus helps organisms survive extreme osmotic stress.
66584-72-3
Ansamitocin P3
Potent cytotoxicity against as a new maytansinoid antitumor antibiotic.
57103-68-1
AP0 Maytansinol
A potent microtubule depolymerizing agent.
139504-50-0
DM1 Mertansine
Cytotoxic component in antibody-drug conjugates
796073-69-3
DM4 Maytansinoid
An intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.
119509-24-9
ATPENIN A5
An inhibitor of SDHB, SDHC and SDHD.
677017-23-1
Berubicin
Intercalating into DNA and interrupting topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
30562-34-6
Geldanamycin
It has potent antineoplastic properties and can inhibit myeloma cell growth.
11011-38-4
Ascomycin
Suppressing immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte.
158440-71-2
Irofulven
Alkylating DNA and protein macromolecules to forms adducts, and arrests cells in the S-phase of the cell cycle.
35846-53-8
Maytansine
A cytotoxic agent that can inhibit the assembly of microtubules by binding to tubulin at the rhizoxin binding site.
47707-78-8
Isofolic acid
An impurity of folic acid.
In addition to payloads, we also provide linkers, payload-linker sets, and comprehensive one-stop solution for ADC research and analysis, ranging from antibody modification and conjugation technologies, ADC payloads development, payload-linker synthesis, ADC conjugation, to various stages of ADC characterization and manufacture.
We will be happy to discuss your ADC projects if you are interested. If not, an explicit answer would also be appreciated. Thank you in advance for your time and consideration.
