MedChemexpress) New Small Molecules for January 2021
작성자
abbabio
작성일자
2021-01-06
조회수
218
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 25,000 bioactive molecules in stock
• High purity & competitive prices
• Target 375 key proteins in 20+ signaling pathways
• Data sheet with detailed biological information
• Quality reports (LC/MS, NMR and HPLC) for each product
• Delivery within 24 hours
• Release more than 500 of the newest biochemicals per month
VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.
WL47, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 (HY-P0052) parent sequence and can be used for the study of caveolin-1 function.
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.
4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.
SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC50s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK with IC50s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated.
1. Nature. 2020 Dec;588(7836):169-173. 2. Cell. 2020 Dec 1;S0092-8674(20)31445-8. 3. Cell. 2020 Dec 15;S0092-8674(20)31615-9. 4. Nat Methods. 2020 Dec 7. DOI: 10.1038/s41592-020-01011-4. 5. Immunity. 2020 Nov 25; S1074-7613(20)30468-4.
