[mdbiosciences] A New Pig Model for Nerve Block Therapies Assessment
작성자
abbabio
작성일자
2019-03-19
조회수
229
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Porcine Models For Improved Clinical Translatability
Now offering a unique model allowing the differentiation between motor dysfunction and pain block following drug application
The problem: the rat model is limited in assessing any local treatment (cream, skin injections, patches and nerve blocks).
The solution:translational models in pigs, prior to clinical stages.
A cutting-edge translational model (technically and scientifically): volume of injection, nerve stimulation, imaging, PK, behavioral changes and skin biomarkers.
By utilizing more translational models in larger species, the success rate of drugs entering clinical phases is dramatically increased.
Unique Model Characteristics
Similar to the clinic - ultrasound guide and nerve stimulation dosing
The study enables the differentiation between motor dysfunction and pain block following drug administration
Various readouts: von Frey-stimulation (primary pain), behavior score, motor function score, open field test, incision score, incision healing (histology) and biomarker analysis in skin
