TMPRSS2 and ACE2, as the central to SARS-CoV-2 (COVID-19) entry into host target cells, scientists are industriously working on the targets and focusing on new drug design. TMPRSS2, an endothelial cell surface protein, on April 23, 2021, a paper published on Nature Medicine (If: 36.13) suggested that TMPRSS2 was significantly expressed in nasal epithelial cells, potentially assuming that drugs/vaccines administered intranasally could be highly effective in limiting COVID-19 spread, which also gives novel insights into clinical research of TMPRSS2 targeted therapy. Interesting reading of TMPRSS2…

CUSABIO has committed to providing the best products and service to enable researchers to better conduct research. At present, we highly recommend our top-selling products recombinant human TMPRSS2 proteins (CSB-YP023924HU; CSB-MP023924HU(M)b0), which boast validated biological activity and different __expression__ systems. Both recombinant TMPRSS2 proteins are in-stock, which might accelerate the TMPRSS2 based drug design and vaccine implementation for our scientists.

Product Information

Recombinant Human TMPRSS2, partial (Active) (Code: CSB-YP023924HU)

Purity>85% (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC). The Km is 21.93μM.

Recombinant Human TMPRSS2(R255Q), partial (Active) (Code: CSB-MP023924HU(M)b0)

Purity>90% (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC). The Km is 19.16μM.

Top Customer Reviews

Anonymous

Applications: Enzymatic activity in vitro

Review: CSB-YP023924HU- TMPRSS2 - Lot DA04630a6g0 works so we will ordering the remaining 950ug of the same lot.

Anonymous

Applications: Enzymatic activity in vitro

Review: We tested the protein and is having positive preliminary results.

Anonymous

Applications: Enzymatic activity in vitro

Review: The enzyme demonstrates good relative activity in our preliminary testing, and should allow us to complete our first round of proposed screening. Once completed, that screening data will be posted on our Open Data Portal (https://opendata.ncats.nih.gov/covid19/), which will include assay details and list you as the source of the enzyme, which I trust will be welcomed by your sales team. To support further screening, we would like to order more, and kindly ask for a new quote for 5mgs, along with an estimated timeline, if possible.