Creative Biolabs) Membrane Protein Stable Cell Lines for Functional Study and Specific Antibody D  
작성자
abbabio
작성일자
2021-05-20
조회수
357
Membrane Protein Stable Cell Lines for Functional Study and Specific Antibody Development
Membrane proteins constitute over thirty percent of all proteins in the human genome and play a vital role in many cellular functions. As such, they represent most current drug targets. Due to their low natural abundance and highly complicated structure, obtaining recombinant membrane proteins with native conformation and bio-activity has always been challenging.
To develop stable cell lines that express membrane proteins, the relative encoding gene fragments are cloned into lentiviral vectors. The generated recombinant vectors are introduced into mammalian cells. After enlarging cultivation and several rounds of screening, the target cells are collected.
Creative Biolabs has over 200 GPCR/ion channel stable cell lines (hosts: CHO/HEK) with high ____expression____ levels of up to 5 million per cell. These cell lines can be directly used for membrane isolation, immunization, and various assays to save your valuable time.
