Cusabio) Articles of Promising CD Molecules in Immunotherapy
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abbabio
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2021-05-27
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315
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In recent years, immunotherapy represents a promising approach in multiple cancers. Particularly, CD molecules play key roles in immune cell-cell communication. Increasing our understanding of their mechanism will be the first step for modern drug discovery in Immunotherapy. Here, CUSABIO offers a series of articles about potential CD molecules to help our customers in immunotherapy research.
SEMA4D/CD100: As an Important Immunoregulator to Improve Immunotherapy
Recently, a study reported that silencing SEMA4D __expression__ inhibits proliferation, autophagy, epithelial-mesenchymal transition, and promotes apoptosis in gastric cancer cells [1]. Back to 2020, ASCO-SITC Clinical Immuno-Oncology Symposium have announced the first SEMA4D-targeted antibody-Pepinemab. Read More>>
With the High Potential in Cancer Immunotherapy, CD40 Is Triggering Attention
CD40 (also known TNFRSF5, tumor necrosis factor receptor superfamily member 5), a 45-50 kDa type I glycoprotein, is a member of tumor necrosis factor receptor (TNFR) superfamily protein [1]. CD40 is widely expressed by antigen presenting cells (APCs) or all stages of B cells [2]. Read More>>
An Overview of CD226 and Its Promising Role in Cancer Immunotherapy
CD226, namely Ig superfamily member DNAX accessory molecule 1 (DNAM-1), is an immunoglobulin superfamily member [3]. Human CD226 gene encodes a 67 kDa glycoprotein (336 amino acids) and is located on chromosome 18q22–23 with length of 2,487 bp [4]. Read More>>
CD73, What a Powerful Therapy Target in Tumor Immune
CD73, also known as Ecto-5'-Nucleotidase, a cell surface enzyme encoded by the NT5E gene, is a major enzyme catalyzing the formation of extracellular adenosine from AMP [1]. The gene for human CD73 is located on chromosome 6q14-921. Read More>>
The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in Cancer
Recently, CD38 causes fresh concerns in the field of anti-aging because two articles published in Nature Metabolis point that CD38 attributes to the NAD+ consumption [1-2]. NAD support is called by some as the "immortality molecule", but NAD+ levels usually decline during aging. Read More>>
As the COVID-19 pandemic evolves, we are with you during these turbulent times. CUSABIO appreciates the critical role that you and our products play in research efforts to further scientific innovation and discovery. We know that many scientists are diligently pursuing their research throughout the pandemic. Our customer service and technical support teams are equipped to remain available to help with your research needs and answer any questions.
