MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
Research Area: Mitochondrial Metabolism/Mitochondrial Pyruvate Carrier
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Highly specific and potent inhibitor of the mitochondrial pyruvate carrier (Ki<0.1 nM) and inhibits mitochondrial respiration supported by pyruvate but not other substrates.
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Inhibits L-lactate transport by the plasma membrane monocarboxylate transporter MCT1.
Solubility: DMF : 5.26 mg/mL (11.16 mM; Need ultrasonic and warming)
Research Area: Autophagy/P2X Receptor/Breast Cancer
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Potent inhibitor of autophagy (IC50=140 nM) that antagonizes the P2X4, P2X1, P2X3 as well as the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50 ranging from 2.4 to 15.4 μM).
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Has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
Solubility: DMSO : 250 mg/mL (477.33 mM; Need ultrasonic and warming)
Selective inhibitor of MLL-rearranged (MLL-r), CALM-AF10 and SET-NUP214 leukemia (IC50=2.5-6.2 μM in sensitive cells).
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Induces a caspase-dependent apoptosis with mitochondrial depolarization. Alters the characteristic MLL-r gene __expression__ signature in sensitive cells with downregulation of the __expression__ of HOXA9, MEIS1, CMYC and BCL2.
Solubility: DMSO : 83.33 mg/mL (247.74 mM; Need ultrasonic)
Patch clamp electrophysiology is the gold standard for ion channel studies. High-throughput identification of compound ion channel efficacy, potency,
specificity, or potential for off-target effects is a critical step in early drug discovery. MCE offers high-throughput fluorescence-based assays, automated patch clamp electrophysiology assays as well as manual patch assays to identify the most promising candidates.
Protein phosphorylation is a key post-translational modification that involves the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc. Kinases and phosphatases contribute to the regulation of protein phosphorylation homeostasis in the cell. MCE kinase inhibitor library contains 1800+ kinase inhibitors and phosphatase inhibitor library contains 80+ phosphatase inhibitors. These two libraries are important tools for protein phosphorylation research and drug discovery used to target a variety of diseases.
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MCE Europe
Tel: +4686500910
E-mail: eu.sales@MedChemExpress.com
Address: Bergkällavägen 37C 192 79 Sollentuna SWEDEN
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