The interactions between proteins are highly specific and play a key role in many cellular processes. Changes in the protein structure such as the distortion of protein interfaces may lead to many diseases. To understand the mechanism of protein recognition at the molecular level and uncover the overall picture of protein interactions in cells, different experimental techniques have been developed: Some characterize individual protein interactions, while others are used to screen interactions on a genome-wide scale.
Here, we summarize the commonly used in vitro and in vivo methods for detecting protein-protein interactions and suggest the most relevant magnetic particles to facilitate your research.
