SARS-CoV-2 pseudotyped lentivirus is replication-incompetent with safe (BSL-2), easy, and high-throughput viral infectivity and can be used in neutralization assays with standard detection instrumentation. It displays an antigenically correct spike protein on a heterologous virus core and carries a modified genome that expresses a convenient optical reporter gene (GFP or luciferase).
Creative Diagnostics has launched a full range of ready-to-use wild-type and newly emerged mutant SARS-CoV-2 pseudotyped lentiviruses to study the interaction between SARS-CoV-2 spike protein and human ACE2 in a physiologically relevant context.
Pseudotyping available with the wild type or mutant spike proteins from a wide range of coronavirus species
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Safe to be used in BSL-2 labs
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Unlimited customization options including the addition of reporter genes for monitoring viral entry
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Quality-controlled production for use as a critical reagent
Resources
SARS-CoV-2 Spike Stable Cell Line
The SARS-CoV-2 spike CHO-K1 cell line has been developed by the stable transfection of the SARS-CoV-2 spike protein plasmid. SARS-CoV-2 spike CHO-K1 cell line provides consistent levels of __expression__ of the SARS-CoV-2 spike protein on the cell surface.
With the demand for vaccine development, Creative Diagnostics has developed two ELISA kits for the qualitative detection of SARS-CoV-2 neutralizing antibodies in serum and plasma. Our competitive assay format measures neutralizing antibodies of the SARS-CoV-2 spike RBD and ACE2 interaction in human plasma and serum.
Coronaviruses are a family of enveloped RNA viruses that infect various mammals as well as birds. Of clinical importance is the Human coronaviruses (HCoVs), which belong to the coronaviridae family. HCoVs have been identified to be a frequent cause of respiratory tract infections, causing mild to severe respiratory diseases.
