Creative Diagnostics) Synthetic Polymer Nanoparticles for Gene Delivery in Gene Therapy      
작성자
abbabio
작성일자
2021-07-13
조회수
363
Synthetic Polymer Nanoparticles for Gene Delivery in Gene Therapy
The field of polymer nanoparticles is rapidly expanding and its development is indispensable in a wide range of fields from electronics, photonics, conductive materials, sensors to medicine, pollution control, and environmental technology. Gene therapy has become one of the most advanced medical applications of polymers among others. However, several barriers related to gene delivery in living systems still need to be addressed by polymer engineering. One of the most critical challenges is the effectiveness of the delivery vehicle or carrier. In recent decades, non-viral delivery systems have attracted attention due to their low toxicity, targeted delivery, long-term stability, lack of immunogenicity, and relatively low production costs. Cationic polymers have the advantages of simple synthesis and flexible performance and have become candidate materials for non-viral gene delivery systems. These polymers can be coupled with genetic materials through electrostatic attraction at physiological pH, thereby promoting gene delivery. The outstanding representatives of polymers used in gene therapy in the past decade are synthetic polymer nanoparticles, such as poly(lactic acid), poly-l-lysine, poly(amidoamine), poly(methyl-methacrylate), poly(ethylene-imine), and poly(lactic-co-glycolide).
This article introduces several common synthetic polymer nanoparticles and their advantages in gene delivery.
