MedChemexpress) New Small Molecules for August 2021
작성자
abbabio
작성일자
2021-08-05
조회수
446
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
Research Area: Dopamine Receptor/Sigma Receptor/Depression
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Potent and selective dopamine D1-like receptor partial agonist with Kis of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors, respectively.
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Potent allosteric modulator of sigma-1 receptor and promotes the binding of 3H(+)-pentazocine to the sigma-1 receptor in brain and liver tissues.
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Shows antidepressant effects.
Solubility: DMSO : 20 mg/mL (50.16 mM; Need ultrasonic and warming)
Research Area: Adrenergic Receptor/Obesity/Cardiovascular disease
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Potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors with Kis of 4, 204 and 390 nM for β3-, β2- and β1-adrenoceptors, respectively.
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Couples predominantly to Gi to activate MAPK signaling.
Solubility: DMSO : 25 mg/mL (50.24 mM; Need ultrasonic and warming)
Specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G.
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Inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM).
Solubility: DMSO : 100 mg/mL (263.67 mM; Need ultrasonic)
Recombinant protein is a protein encoded by a recombinant DNA that has been cloned in a system that supports __expression__ of the gene and translation of mRNA. The host cells used for recombinant protein production can be derived from bacteria, mammalian cell, insect and yeast. MCE contains more than 2,500+ recombinant proteins with different functions, which can be used for biological research in many different research fields such as humans, mice, rats, monkeys, pigs, dogs, and cattle.
• Broad Categories • High Purity • Low Endotoxin Levels • Superior Biological Activity • Excellent Lot-to-Lot Consistency • High-scoring Literature Citation
Natural Product Library
Natural products (NPs) and their molecular frameworks are the main sources of new drugs and play a highly significant role in the drug discovery and development process. In fact, about two-thirds of all small molecule drugs approved between 1981 and 2019 are related, to different extents, to NPs. MCE provides a unique collection of 3,000+ natural compounds that have clear source and structure classification. MCE Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).
