[MedChemExpress] New Small Molecules for September 2021
작성자
abbabio
작성일자
2021-09-06
조회수
446
MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 30,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
Stimulates D2R G protein-mediated signaling (EC50=0.37 μM in a calcium mobilization assay) and acts as an antagonist for dopamine (DA)-stimulated β-arrestin recruitment to the D2R.
Solubility: DMSO : 50 mg/mL (140.91 mM; Need ultrasonic)
Orally active, selective PKC beta (PKCβ) inhibitor (Ki=2 nM) and inhibits the PKC beta I (IC50=4.7 nM) and PKC beta II (IC50=5.9 nM) isozymes.
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Exhibits ATP dependent competitive inhibition of PKC beta I and is selective for PKC in comparison to other ATP dependent kinases (protein kinase A, calcium calmodulin, casein kinase, src tyrosine kinase).
Solubility: DMSO : 50 mg/mL (106.71 mM; ultrasonic and warming to 60°C)
MCE Renilla-Firefly Luciferase Dual Assay Kit contains high-purity D-Luciferin, coelenterazine and proprietary reaction buffer. This product is ideal for the detection of both Firefly luciferase and Renilla luciferase in mammalian cells.
Antibody-drug conjugate (ADC), a chimeric or humanized monoclonal antibody tethered to a highly potent drug (payload) through a cleavable or non-cleavable linker, is an emerging novel class of anticancer drugs and has great potential to make a paradigm shift in cancer chemotherapy. The key factors to design antibody-drug conjugates are the rational selections of payload, linker or drug-linker conjugate, antibody, and conjugation strategy. MCE can provide one-stop services for the design, synthesis, analysis, purification, optimization, detection and evaluation of 900+ ADC-related products (ADC Cytotoxin, ADC Linker, Drug-Linker Conjugates for ADC, and ADC).
