Utilization of Known Compounds is the Most Frequent Lead
Generation Strategy
Brown and Bostrom analyzed 66 clinical candidates during 2016−2017 and
found that the most frequent lead generation strategy was based on starting
points derived from previously known compounds (43%) followed by random
high throughput screening (29%) [1].
AI-Powered Drug Discovery
Furthermore, artificial intelligence
(AI) has become an important tool
applied ubiquitously in various
stages of drug development [2].
It has great potential to enhance
and accelerate drug discovery.
Recently, AlphaFold2 has made
big progress in protein structures
Distribution of the six sources of
lead generation strategies
prediction, which is considered as a big leap in the biological world [3]!
With the development of technology, several strategies have emerged to meet the demand for accelerating drug discovery. Which one is the best strategy? Perhaps the answer is the integrated strategy.
MedChemExpress (MCE) can provide different kinds of compound libraries. All compounds are in stock and can be resupplied. Useful tools for mechanism research and drug discovery. High purity and quality of compounds is validated by NMR and LC/MS.
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