[Cusabio] Hot Protein - Transthyretin (TTR) Protein From CUSABIO
작성자
abbabio
작성일자
2019-04-11
조회수
392
Self-introduction of TTR
Transthyretin (TTR) is also known as vitamin A binding protein, prealbumin (PA), and thyroid-binding pre-albumin. It is mainly active in serum and cerebrospinal fluid. It is named for its ability to transport thyroxine and retinol. TTR is a carrier of the thyroid hormone thyroxine (T4) and retinol binding protein in combination with retinol.
The ability of TTR
Thyroxine plays an important role in the development and maintenance of human body. Vitamin A deficiency is also a major cause of night blindness. As a transport protein of thyroxine and retinol, TTR expression can reflect the body's nutrition and some pathological changes, and can be used as an indicator to predict and judge the prognosis of diseases. In some tumors, TTR can be used as a biomarker to improve the diagnostic level.
TTR and disease
TTR is associated with a variety of diseases in humans. It is known that TTR misfolding and aggregation are associated with amyloid diseases such as senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). In addition, TTR is closely related to type 2 diabetes.
TTR and tumor
TTR is associated with pancreatic cancer, primary liver cancer, ovarian cancer, colon cancer and rectal cancer. In the diagnosis of ovarian cancer, TTR is considered to be an ideal biomarker. TTR combined with other proteins such as retinol binding protein, apolipoprotein (Apo) III, etc., can significantly improve the level of adjuvant diagnosis of early ovarian cancer. TTR protein can also be used as a candidate marker in the diagnosis of colorectal cancer.
TTR also has diagnostic value for brain tumors. More details please click here.
