MedChemexpress) New Small Molecules for October 2021
작성자
abbabio
작성일자
2021-10-05
조회수
580
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 30,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
Research Area: Somatostatin Agonist/Acromegaly and Cushing's Disease
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A long-acting cyclohexapeptide somatostatin analogue with high binding affinity for somatostatin receptor subtypes (pKis of 8.2, 9.0, 9.1, <7.0, and 9.9 for somatostatin receptor subtypes 1, 2, 3, 4, and 5, respectively).
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Potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease.
Solubility: DMSO : 100 mg/mL (90.31 mM; Need ultrasonic)
MedChemExpress (MCE) Anti-Flag Affinity Gel is a purified mouse IgG2b monoclonal antibody covalently attached to agarose Sepharose 4B. With high protein-binding capacity and stability, this product is ideal for high performance purification or immunoprecipitation (IP) of Flag-tagged proteins expressed in E.coli, yeast, insect and mammalian ____expression____ systems.
Characteristics
Isotype
Mouse IgG2b
Application
Protein Purification, IP, Co-IP
Binding Capacity
Minimum 1.1 mg of fusion protein per mL of gel
Volume
5 μL gel for 500 μL lysate
Storage Buffer
50% glycerol, 10 mM Na3PO4, 150 mM NaCl, 0.02% (w/v) sodium azide, pH 7.4
MedChemExpress (MCE) PolyFast Transfection Reagent consists of cationic polymers and can introduce nucleic acids (DNA or RNA) into eukaryotic cells. PolyFast Transfection Reagent has high-efficiency, low-toxicity transfection of many cell types, including some hard-to-transfect cells.
PROTAC (PROteolysis-TArgeting Chimera) is a heterobifunctional nanomolecule containing two different ligands, ligand for ubiquitin E3 and ligand for target protein. The two parts are connected by linker to form a "three-unit" polymer, target protein ligand-linker-E3 ligase ligand. Building blocks of PROTAC molecules include PROTAC Linker, Ligand for Target Protein for PROTAC, Ligand for E3 Ligase, E3 Ligase Ligand-Linker Conjugate, Target Protein Ligand-Linker Conjugate, etc. MedChemExpress (MCE) provides 3,000+ PROTAC products (PROTAC and its building blocks), as well as one-stop services for design, synthesis, activity screening and structural optimization of PROTAC. Each service can also be customized independently.
