[CUSABIO] What You Have To Know About TGF-β, A Double-Edged Sword
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abbabio
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2019-01-24
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221
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TGF-β is a growth factor with multi-function on target cells. Almost every cell in the body produces TGF-β and has its receptor. It plays an important regulatory role in the differentiation of tissues and cells, and can stimulate or inhibit the proliferation of various cells. In addition, it has a significant impact on the body's immune system. They play an important role in tumorigenesis and metastasis. A sweet guy from CUSABIO has introduced TGF-β from the following aspects.
The overview of TGF-β signaling pathway
Transforming growth factor β signaling pathway is a series of signal transduction processes mediated by transforming growth factor. TGF-β signaling pathway plays a key role in cell proliferation, interstitial production, differentiation, apoptosis, embryonic development, organ formation, immune function and inflammatory response. Read More
Double-Edged Sword: TGF-β
In tumor cells, the role of TGF-β family is to regulate the balance between self-repair and differentiation of cancer stem cells (CSCs). It has dual effects on tumor cells. TGF-β signaling switches from a tumor suppressor to a tumor promoter are shown. Read More
Do You Really Know TGF-β Superfamily?
Since the discovery of the first member of TGF-β family in the early 1980s, related members have been identified and functionally characterized, in a superfamily now numbering more than 30 ligands in mammals. The TGF-β superfamily consists of a variety of proteins that regulate different physiological functions. Read More
