Breast cancer is cancer that develops from breast tissue. Risk factors for developing breast cancer include being female, obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. BT LAB offer a list of very promising protein biomarkers for breast cancer research.
Tools for analyzing the IHC for breast cancer research
Estrogen receptor/ER
Estrogen receptors are over-expressed in around 70% of breast cancer cases, referred to as "ER-positive", and can be demonstrated in such tissues using immunohistochemistry. Two hypotheses have been proposed to explain why this causes tumorigenesis, and the available evidence suggests that both mechanisms contribute. BT-MCA0518 ER Alpha monoclonal antibody
progesterone/PR
Progesterone plays an important role in breast development in women. In conjunction with prolactin, it mediates lobuloalveolar maturation of the mammary glands during pregnancy to allow for milk production and thus lactation and breastfeeding of offspring following parturition. Estrogen induces __expression__ of the PR in breast tissue and hence progesterone is dependent on estrogen to mediate lobuloalveolar development. BT-AP07375 PR Polyclonal Antibody
ERBB2/HER2
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. BT-AP05901 Neu Polyclonal Antibody
Ki67
In breast cancer Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy. Ki-67 can independently predict prognosis of patients with operable breast cancer. BT-MCA0803 Ki67 monoclonal antibody
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Any BT-LAB product are for Research Use Only, Not for use in diagnostic procedures.
