MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 30,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
Research Area: 5-HT7 Receptor Antagonist/Cancer and Neurological Disease
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Potent and selective 5-HT7 receptor antagonist with high affinity (pKi=7.5).
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Antagonizes surmountably 5-CT-stimulated adenylyl cyclase activity and reduces proliferation of HuH-7 and HepG2 cells, and also down regulates β-catenin.
Solubility: DMSO : 250 mg/mL (738.53 mM; Need ultrasonic)
MCE SYBR Green qPCR Master Mix (Universal) is compatible with all qPCR instruments. 2× ready-to-use formulations which consist of antibody-mediated hot start polymerase, MgCl2, dNTPs and a proprietary reaction buffer, produce optimal results in qPCR experiments.
Comparison of chemical and antibody hot-start technologies
Hot-start technology
Introduction
Features
Chemical-mediated
Polymerases are covalently linked with chemical groups to block enzyme activity at room temperature. As temperature rises, chemical bonds break and enzyme activity is restored.
Long activation time; Full activation of the enzyme is often not possible; Free of animal-origin components.
Antibody-mediated
Polymerases are bound by antibodies at their active sites to block enzyme activity at room temperature. As temperature rises, antibodies get denatured and enzyme activity is restored.
Short activation time; Full enzyme activity is restored after activation; Antibodies may be of animal origin and may cause contamination of the PCR sample.
Anti-infection Related Libraries
COVID-19 continues to spread globally and imposes a heavy burden on society. Infections caused by pathogens such as viruses, bacteria, fungi, and parasites pose a serious threat to people's health. Furthermore, resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. So it is urgent to develop novel and effective anti-infection drugs. MCE provides a unique collection of 1800+ anti-infection compounds with confirmed anti-bacterial, anti-viral, anti-fungal, and anti-parasite activities that can be used for anti-infection drug screening and mechanism research.
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