[MedChemExpress ; MCE] New Small Molecules for December 2021
작성자
abbabio
작성일자
2021-12-03
조회수
551
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 30,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via sales@MedChemExpress.com.
Combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics.
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SG3199 is the released warhead component of Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines.
Solubility: DMSO : 200 mg/mL (133.63 mM; Need ultrasonic)
Research Area: PPARγ Agonist/Hyperglycemia/ Hypertriglyceridemia/Type 2 Diabetes
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An orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM) and functions as a PPARγ agonist with potent anti-diabetic activity in vivo.
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Has different effects on the activation of PPARγ at each stage of adipocyte differentiation.
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Used for the research of hyperglycemia, hypertriglyceridemia, glucose intolerance and type 2 diabetes.
Solubility: DMSO : 100 mg/mL (213.49 mM; Need ultrasonic)
Orally bioavailable dinucleotide that significantly reduces liver hepatitis B virus (HBV) DNA in transgenic mice expressing HBV.
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Acts as a RIG-I (Retinoic acid-inducible gene-I) agonist, activates the viral sensor proteins RIG-I and NOD2, and triggers the induction of the interferon signaling cascade for antiviral defense.
Solubility: DMSO : 100 mg/mL (165.42 mM; Need ultrasonic)
MCE provides commonly used biological buffers in the form of instant powders. Using AR/GR grade raw materials, the powders are fully mixed through technological innovation and process upgrading, thus leading to stronger uniformity. The powders can be quickly dissolved into a buffer solution by adding water. Compared with traditional powders, MCE instant powders are simple to operate, eliminating the need for tedious weighing and pH adjustment steps, which can greatly save experimental time and reduce experimental errors.
Natural Products: Xanthones
Phenols are a broad class of natural products with phenolic hydroxyl groups (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others), which have antioxidant and other pharmacological activities. Xanthones are a class of simple tricyclic compounds, which are mainly secondary metabolites from plants (such as mangosteen, lichen) and microorganisms (such as bacteria and fungi). These compounds have a wide range of pharmacological activities, including antihypertensive, antioxidation, antithrombotic, and anticancer activities.
Activator of Nrf2 that suppresses nuclear translocation of the NF-κB subunits p65 and p50. Exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and anti-inflammatory activities.
Inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Exerts antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects.
Antagonist of antiapoptotic Bcl-2 family proteins against Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 (IC50s ranging from 0.66 to 2.02 μM). Exerts anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects.
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