Cyclopentane skeleton widely exists in many synthetic and natural bioactive molecules (prostaglandins, steroids, terpenoids, etc.)[1]. In order to minimize torsional strain, cyclopentane puckers to adopt an “envelope” conformation. Cyclopentanes on drugs may serve as either the core scaffold or an appendage to occupy a hydrophobic pocket of the target such as an enzyme or a receptor. Due to its unique properties, more and more building blocks containing cyclopentane are used in drug design[2-7].
A series of medicinal products containing Cyclopentane have been firmly incorporated in medical practice
[1] The Journal of Organic Chemistry (2015), 80, 24, 12212-12223. [2] Journal of Medicinal Chemistry (2013), 56, 23, 9789-9801. [3] Journal of Medicinal Chemistry (2019), 62, 5, 2265-2285. [4] Journal of Medicinal Chemistry (2018), 61, 20, 9218-9228. [5] Journal of Medicinal Chemistry (2015), 58, 3, 1281-1297. [6] European Journal of Medicinal Chemistry (2021), 214,113194. [7] European Journal of Medicinal Chemistry (2015), 93, 121-134.
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