MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
• Over 30,000 bioactive molecules in stock
• Target 500+ key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 newest biochemicals per month
Research Area: CLK1/CLK4 Inhibitor/Alzheimer's Disease/Influenza A Virus
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Potent and selective inhibitor of CLK1 and the closely related isoform CLK4 (CDC2-like kinase isoforms 1/4), with IC50s of 16.5 nM and 488 nM for CLK1 and CLK3, respectively.
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Inhibits DYRK1A with an IC50 of 57.8 nM.
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CLK kinases are key regulators of protein splicing.
Solubility: DMSO : 100 mg/mL (295.69 mM; Need ultrasonic)
Research Area: BCR-ABL Inhibitor/Chronic Myeloid Leukemia
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Potent, orally active inhibitor of BCR-ABL tyrosine kinase, including both wild-type and T315I Bcr-Abl.
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Arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells.
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Inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β.
Solubility: DMSO : 65 mg/mL (129.36 mM; ultrasonic and warming to 60°C)
Research Area: Aspartate Transcarbamoylase Inhibitor/Colon Cancer/B16 Melanoma
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Potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis.
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A DNA antimetabolite agent, synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines.
Solubility: H2O : 250 mg/mL (778.67 mM; Need ultrasonic)
MCE PolyFast Transfection Reagent (HY-K1014) consists of cationic polymers. It can introduce nucleic acids (DNA or RNA) into eukaryotic cells.
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High Transfection Efficiency
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Low Cytotoxicity
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Widely applicable to many cell lines
High Transfection Efficiency
Validated Partial Cell Lines
293T
BHK-21
HuH-7
HepG2
Vero
HMEC-1
U118 MG
SKNSH
CHO-K1
MDCK
THP-1
K562
C6/36
A549
HT-29
HeLa
HUVEC
SP2/0
P3X63Ag8
PBMCs
Natural products: Terpenoids
The terpenoids are derived from mevaleryl acid and their molecular formula can be written as (C5H8) n as a general formula. The skeleton is usually based on five carbons, with a few exceptions (possibly due to isomerization or degradation reactions during formation). Terpenoids are a kind of secondary metabolites with the largest variety and the most abundant chemical structure changes in natural products, which have important medicinal value, such as Paclitaxel from Taxus chinensis, Artemisinin from Artemisia annua, and Triptolide from Tripterygium wilfordii.
An immunomodulator; Enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50s of 512.42 and 500.16 μM, respectively.
Unsaturated optically active sesquiterpene alcohol with neuroprotective effects; Has antioxidant, anti-inflammatory, and anti-apoptotic activities; Orally active.
A phytohormone regulating plant growth, development, and stress responses; Also present in animals, where it is involved in the regulation of innate immune cell function and of glucose disposal, through its receptor LANCL2. Orally active.
Bioactive constituent of Radix Bupleuri with anticancer activity; Significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO.
A labdane diterpene with calcium channel blocking activity; Desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.
