Polyethylene glycol (PEG) is increasingly used in pharmacotherapy as a polymer for bioconjugation. To date, more than 20 PEGylated proteins, peptides, Ab fragments, and oligonucleotides have been approved by the FDA for research purposes. The defined qualitative and quantitative analysis of PEGylated compounds in biological samples is important for drug development and pharmaceutical manufacturing applications. Creative Diagnostics has developed a series of specific anti-PEG monoclonal antibodies. These antibodies have been validated to work in various types of immunoassays and can be supplied as high-quality research tools to quantify PEGylated target molecules in complex matrices to monitor drug levels or accumulations in tissue. We now provide combo packages of small sizes so that customers can choose the most suitable ones for research applications.
Application of Polyethylene Glycol (PEG) in the Medical Field
Polyethylene glycol has the lowest absorption level by proteins and cells among all known polymers. Polyethylene glycol is highly soluble in water, ethanol, and most commonly known solvents at room temperature. It is non-toxic, harmless, and non-irritating to the human body and has good biocompatibility, lubricity, and moisture retention.
Creative Diagnostics provides ELISA kits for the measurement of free and conjugated PEG as well as ELISA kits for the detection of anti-PEG IgM and IgG in mouse, rat, monkey, and human serum/plasma. These assay kits are useful in clinical safety studies in determining the immunogenicity of PEGylated biotherapeutics.
