On March 17, 2022, TODD R. GOLUB's team from Harvard University and MIT published a research paper on the Science entitled "Copper induces cell death by targeting lipoylated TCA cycle proteins". The scientist discovered a new kind of cell death linked to copper--naming it "Cuprotosis" (Click to read "Cuprotosis"feature articles).

In fact, Apoptosis, Pyrolysis, Necrosis and Ferroptosis are the most traditionally and extensively studied forms of cell death in recent years. However, "Cuprotosis" is distinct from the traditional modes of cell death. Apparently, it will be a hot topic for future research in diseases caused by disorders of copper, including Wilson’s disease, Menke’s disease, and tumors. (Click to read "Cell Biology" feature articles).

TODD R team provides insight into the mechanism of a copper-triggered cell death.

In this study, a series of key genes were discovered mainly responsible for the "Cuprotosis" regulation mechanism. Here, CUSABIO has summarized the hot targets of antibody products in the "Cuprotosis" regulation mechanism to support your research on "Cuprotosis" (See table below).

A Summary of Hot Targets of Antibody Products in the "Cuprotosis"