As the most abundant free amino acid in the plasma, glutamine participates in a variety of biochemical processes, such as protein and lipid synthesis, cellular energy production, and nitrogen and carbon donation. Glutamine metabolism occurs in proliferating cells, particularly cancer cells. The process begins with glutamine entering the cell through the amino acid transporter ASCT2/SLC1A5. In the mitochondria, glutamine undergoes glutaminolysis, which includes reaction steps from the citrate cycle and the malate-aspartate shuttle. Through glutamine metabolism, glutamine serves as a significant energy source for cancer cells and stimulates tumor growth. As a result, scientists have been investigating how the pathway can be targeted to treat cancer. Click below to view & download the glutamine metabolism pathway.
Boster takes great measures to ensure product quality and to provide our customers with comprehensive data upfront. Our antibodies are validated using WB, IHC, and flow cytometry against a panel of over 250 tissues and un-transfected cell lines to ensure high affinity and crystal-clear IHC stains. In addition, we also validate our antibodies in a quantitative fashion by testing them on known quantities of recombinant proteins so that you know what to expect (e.g. if there is 1ng, 2.5ng or 5ng of the target protein in the sample). Every product is covered by the Boster Quality Guarantee, click below to learn more.
